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CHOCOlate MeLatonin for AdolescenT MigrainE (CHOCOLATE)

April 24, 2019


Melatonin in commonly known as the chemical produced naturally in your brain to promote restful sleep. You can also purchase supplements that increase the production of melatonin. Now, the University of California is researching the effectiveness of melatonin in different doses, given in chocolate, to children and teens who suffer from migraines.


Study Information

This study aims to treat the pain of migraines in children and tennagers through various doses of melatonin in chocolate. It has an estimated 100 participants. It began on September 25, 2017 and is estimated to be completed on September 2, 2022.


Inclusion Criteria


  • Meets the International Classification of Headache Disorders (ICHD) criteria for episodic migraine in children and teenagers who have at least an average of 1 migraine per month
  • Ages 3-17
  • Dissatisfaction with previous acute treatments for migraines, for one or more of the following reasons: a) One or more previously tried acute medications have not been effective, or adequately effective, b) previously tried acute treatments have caused side effects, or C) patient/family would prefer a natural supplement for acute treatment over medication treatment
  • If of driving age, teen participant agrees not to drive for at least 8 hours after treatment with melatonin


Exclusion Criteria


  • Allergy or intolerance to melatonin, or to chocolate
  • Opioid or barbiturate overuse
  • Pregnant/lactating



You may participate at this study at the University of California in San Francisco, California 94158. If you have any questions or concerns, please contact Amy A. Gelfand, M.D. at 415-885-7832 or at You may also contact Laura Dapkus, NCPT at 415-860-2202 or at



This study is sponsored by the University of California.

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